C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 5/078 (2010.01) C12N 5/0781 (2010.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2633157
The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
L'invention concerne une méthode permettant d'influencer la stabilité d'une cellule produisant des anticorps, consistant à influencer directement ou indirectement la teneur en produit d'expression BCL6 et/ou Blimp 1 de ladite cellule produisant des anticorps. L'invention concerne également des cellules et des lignées cellulaires produisant des anticorps stables, ainsi que des méthodes destinées à la production d'anticorps, dans lesquelles sont utilisées ces cellules et/ou ces lignées cellulaires.
Beaumont Tim
Diehl Sean Andrew
Scheeren Ferenc Alexander
Spits Hergen
Academisch Medisch Centrum Bij de Universiteit Van Amsterdam
Aimm Therapeutics B.v.
Borden Ladner Gervais Llp
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