Means and methods for manipulating hypersensitivity-like...

Details Means and methods for manipulating hypersensitivity-like... Means and methods for manipulating hypersensitivity-like...

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) A61K 38/17 (2006.01) A61P 37/00 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2478649

Immunoglobulin light chains (Ig-LC) are produced in excess in animals compared to heavy chains. The present invention implicates these Ig-LC in hypersensitivity responses and provides means and methods for manipulating the responses. The invention further provides a common gamma chain independent receptor on mast cells capable of mediating the mentioned effects of Ig-LC. In response to activation of the pathway of which the found receptor is a part, a mast cell is activated and stimulated to degranulate.

Des chaînes légères d'immunoglobulines (Ig-LC) sont produites en excès chez les animaux en comparaison aux chaînes lourdes. Selon la présente invention, ces chaînes légères d'immunoglobulines (Ig-LC) sont impliquées dans des réponses d'hypersensibilité. Ladite invention concerne donc des dispositifs et des méthodes de manipulation des réponses, ainsi qu'un récepteur indépendant de la chaîne gamma commune sur des mastocytes capables de médier les effets mentionnés des chaînes légères d'immunoglobulines (Ig-LC). Suite à l'activation de la voie de passage dont fait partie le récepteur susmentionné, un mastocyte est activé et stimulé pour entraîner la dégranulation.

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