Means and methods for mediating protein interference

Details Means and methods for mediating protein interference Means and methods for mediating protein interference

A - Human Necessities

61

K

A61K 38/16 (2006.01)

Patent

CA 2632331

The present invention belongs to the field of functional proteomics and more particularly to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non- naturally, user-designed molecule, designated as interferor, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such interferor molecules and their use in therapeutic applications.

La présente invention concerne le domaine de la protéomique fonctionnelle, et plus particulièrement le domaine de l'agrégation protéinique. La présente invention porte sur une méthode d'interférence avec le fonctionnement d'une protéine cible et les applications d'une molécule non naturelle spécialement conçue, désignée comme étant l'interférent, qui présente une spécificité vis-à-vis d'une protéine cible et qui induit l'agrégation lors de sa mise en contact avec ladite protéine cible. La présente invention concerne également de telles molécules d~interférent ainsi que leur emploi dans des applications thérapeutiques.

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