Means and methods for modifying gene expression using...

Details Means and methods for modifying gene expression using... Means and methods for modifying gene expression using...

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2381921

Methods and means are provided for reducing expression of a nucleic acid of interest, thereby altering the phenotype of an organism, particularly a plant, by providing aberrant, preferably unpolyadenylated, target specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by expresssion of a chimeric DNA construct comprising a promoter, a DNA region encoding the target specific RNA, a self-splicing ribozyme and a DNA region involved in 3' end formation and polyadenylation.

L'invention concerne des moyens et des méthodes permettant de réduire l'expression d'un acide nucléique, ce qui permet de modifier le phénotype d'un organisme, notamment d'une plante, en fournissant un ARN spécifique de cibles, aberrant et de préférence non polyadénylé, au noyau de la cellule hôte. De préférence, cet ARN non polyadénylé et spécifique de cibles est obtenu au moyen de l'expression d'une construction d'ADN chimérique comprenant un promoteur, une région d'ADN codant pour l'ARN spécifique de cibles, un ribozyme à auto-épissage et une région d'ADN jouant un rôle dans la polyadénylation et la formation de terminaison 3'.

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