Means and methods for monitoring nucleoside reverse...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) A01N 43/04 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C08G 18/12 (2006.01) C09J 4/06 (2006.01) C12N 13/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/70 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2341679

This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) and further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy, particularly nucleoside reverse transcriptase inhibitor therapy using phenotypic susceptibility assays or genotypic assays.

L'invention concernre des analyses de sensibilité et de résistance aux médicaments antiviraux destinées à être effectuées pour identifier les schémas posologiques permettant de traiter efficacement les infections à VIH (virus de l'immunodéficience humaine) et le SIDA (syndrome d'immunodéficience acquis). Cette invention concerne également des méthodes et des moyens permettant de contrôler l'évolution clinique des infections à VIH ainsi que sa réponse à une thérapie antirétrovirale, en particulier une thérapie qui utilise l'inhibiteur de la reverse-transcriptase nucléosidique et s'appuie sur des tests de sensibilité phénotypiques ou des tests génotypiques.

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