Means and methods for the production of amyloid oligomers

Details Means and methods for the production of amyloid oligomers Means and methods for the production of amyloid oligomers

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2662723

The present invention relates to the field of amyloid disorders, more particularly to the field of diseases where protein misfolding leads to the generation of insoluble amyloid fibers in tissues and organs. The invention provides methods for the production of soluble, toxic amyloid oligomers. The invention further provides assays using said amyloid oligomers to screen for molecules that interfere with the toxicity of said oligomers.

La présente invention concerne le domaine des troubles amyloïdes, plus particulièrement le domaine des maladies où le mauvais repliement des protéines conduit à la génération de fibres amyloïdes insolubles dans les tissus et les organes. L'invention propose des procédés pour la production d'oligomères amyloïdes toxiques solubles. Elle concerne en outre des essais utilisant lesdits oligomères pour cribler des molécules qui interfèrent avec la toxicité desdits oligomères.

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