A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/49 (2006.01) A61K 31/203 (2006.01) A61K 31/60 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 39/00 (2006.01) A61P 7/00 (2006.01)
Patent
CA 2540529
The present invention relates to new methods of modulating stem/progenitor cell recruitment and is based on the discovery that molecules that agonize the formation of plasmin can stimulate the recruitment of stem/progenitor cells, including hematopoietic andendothelial precursor cells. Conversely, antagonists of plasmin can inhibit recruitment of said stem cells. In addition, the identification of the uPA receptor (uPAR) as a retention signal for stem cells in their niche suggests a novel method for increased engraftment and isolation of multipotent stem cells.
La présente invention concerne des nouveaux procédés permettant de moduler le recrutement de cellules souches/progénitrices fondés sur la découverte selon laquelle les molécules augmentant la formation de plasmine peuvent stimuler le recrutement des cellules souches/progénitrices, y compris les précurseurs hématopoïétiques et les cellules endothéliales. Réciproquement, des antagonistes du plasmine peuvent bloquer le recrutement de ces cellules souches. En outre, l'identification du récepteur uPA (uPAR) en tant que signal de rétention pour les cellules souches dans leur niche donne lieu à un nouveau procédé permettant d'obtenir une meilleure prise de greffe et un meilleur isolement de cellules souches multipotentes.
Carmeliet Peter
Tjwa Marc
D. Collen Research Foundation Vzw
Fetherstonhaugh & Co.
Vib Vzw
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