A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/277 (2006.01) A61K 31/185 (2006.01) A61K 31/343 (2006.01) A61K 31/4422 (2006.01) A61K 31/47 (2006.01) A61K 31/64 (2006.01) A61K 38/13 (2006.01) A61P 19/02 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2533846
The present invention relates to the use of at least one inhibitor of at least one ABC-~transporter capable of transporting hyaluronan across a lipid bilayer, such as verapamil or valspodar, for the preparation of a pharmaceutical composition for the treatment of a disease which is associated with an excess transport of hyaluronan across a lipid bilayer, e.g. arthritis. Furthermore, the present invention relates to a method for screening a compound which is suitable for the treatment of a disease which is associated with an excess transport of hyaluronan across a lipid bilayer, e.g. arthritis. The present invention also relates to a method for screening a compound which reduces the transport of hyaluronan mediated by (an) ABC-transporter(s). Furthermore, the present invention relates to a method for identifying a subject at risk for a disease which is associated with an excess transport of hyaluronan across a lipid bilayer, e.g. arthritis as well as to a method of screening for a compound which is suitable for the treatment of a disease which is associated with an excess transport of hyaluronan across a lipid bilayer, e.g. arthritis in a subject. In addition, the present invention relates to a method of preventing, ameliorating and/or treating the symptoms of a disease which is associated with an excess transport of hyaluronan across a lipid bilayer, e.g. arthritis in a subject.
La présente invention concerne l'utilisation d'au moins un inhibiteur d'au moins un transporteur ABC capable de transporter l'hyaluronane à travers la bicouche lipidique, pour préparer une composition pharmaceutique destinée au traitement d'une maladie liée à un excès de transport de l'hyaluronane à travers le bicouche lipidique, par exemple l'arthrite. L'invention concerne également un procédé de tri d'un composé qui est destiné au traitement d'une maladie liée à un excès de transport de l'hyaluronane à travers la bicouche lipidique, par exemple l'arthrite. L'invention concerne un procédé de tri d'un composé qui réduise le transport de l'hyaluronane à médiation par au moins un transporteur ABC. La présente invention concerne encore un procédé d'identification d'un patient susceptible de souffrir d'une maladie liée à un excès de transport de l'hyaluronane à travers la bicouche lipidique, par exemple l'arthrite, ainsi que le procédé de tri d'un composé destiné au traitement d'une maladie liée à un excès de transport de l'hyaluronane à travers la bicouche lipidique, par exemple l'arthrite, chez un patient. Enfin, la présente invention concerne un procédé de prévention, d'amélioration et/ou de traitement des symptômes d'une maladie liée à un excès de transport de l'hyaluronane à travers la bicouche lipidique, par exemple l'arthrite, chez un patient.
Ridout & Maybee Llp
Universitaetsklinikum Muenster
LandOfFree
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