Means and methods for treatment evaluation

Details Means and methods for treatment evaluation Means and methods for treatment evaluation

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2369183

The invention provides a method for determining whether a treatment is effective in changing the status of a certain set of target cells, such as a tumor, in a patient. This method implies obtaining a sample from a patient after initiation of a treatment, and determining whether said sample comprises an expression product of at least one marker gene. Preferably, said sample is a blood sample. In one aspect, said expression product is expressed by a peripheral blood mononuclear cell. Said marker gene may be a gene involved in the generation, maintenance and/or breakdown of blood vessels (angiogenesis). A method of the invention is vary suitable to determine within a few days if a certain treatment against Kaposi's Sarcoma is successful. Moreover, this method is suitable for determining the presence of angiogenesis and/or tumor cells in a patient.

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