Means for inhibiting the expression of cd31

Details Means for inhibiting the expression of cd31 Means for inhibiting the expression of cd31

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2649020

The present invention is related to a nucleic acid molecule comprising a double-stranded structure, whereby the double-stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and said first stretch is at least partially complementary to a target nucleic acid, and whereby the second strand comprises a second stretch of contiguous nucleotides and said second stretch is at least partially complementary to the first stretch, whereby the first stretch comprises a nucleic acid sequence which is at least complementary to a nucleotide core sequence of the nucleic acid sequence according to SEQ. ID.No. 1, whereby the nucleotide core sequence comprises the nucleotide sequence from nucleotide positions 1277 to 1295 of SEQ. ID.No 1; from nucleotide positions 2140 to 2158 of SEQ.ID.No.l; from nucleotide positions 2391 to 2409 of SEQ.ID.No.l; and whereby the first stretch is additionally at least partially complementary to a region preceding the 5' end of the nucleotide core sequence and/or to a region following the 3' end of the nucleotide core sequence.

La présente invention concerne une molécule d'acide nucléique comprenant une structure bicaténaire, la structure bicaténaire comprenant un premier brin et un second brin, le premier brin comprenant une première suite de nucléotides contigus et ledit premier brin étant au moins partiellement complémentaire d'un acide nucléique cible, et le second brin comprenant une seconde suite de nucléotides contigus et ledit second brin étant au moins partiellement complémentaire de la première suite, la première suite comprenant une séquence d'acides nucléiques qui est au moins complémentaire d'une séquence nucléotidique de base de la séquence d'acides nucléiques selon SEQ.ID.NO. 1, la séquence nucléotidique de base comprenant la séquence nucléotidique s'étendant des positions nucléotidiques 1277 à 1295 de SEQ.ID.NO. 1; des positions nucléotidiques 2140 à 2158 de SEQ.ID.No.l; des positions nucléotidiques 2391 à 2409 de SEQ.ID.No.l; et la première suite étant en outre au moins partiellement complémentaire d'une région précédant l'extrémité 5' de la séquence nucléotidique de base et/ou d'une région suivant l'extrémité 5' de la séquence nucléotidique de base.

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