Means for obtaining avirulent leishmania promastigotes,...

Details Means for obtaining avirulent leishmania promastigotes,... Means for obtaining avirulent leishmania promastigotes,...

C - Chemistry, Metallurgy

12

N

C12N 15/79 (2006.01) A61K 39/008 (2006.01)

Patent

CA 2597512

The invention relates to an expression vector of a gene coding for an antigenic protein of Leishmania promastigote, characterised in that it comprises a PSA gene insert in opposite orientation. The invention can be applied to the development of mutants under-expressing, or no longer expressing, genes coding for an antigenic protein of Leishmania promastigote, and to the therapeutic and/or vaccine-oriented uses thereof.

Vecteur d'expression d'un gène codant une protéine antigénique de promastigote de leishmanie, caractérisé en ce qu'il comprend un insert de gène PSA dans une orientation antisens. Application à l'élaboration de mutants sous-exprimant ou n' exprimant plus de gène codant une protéine antigénique de promastigote de leishmanie et à leurs utilisations thérapeutiques et/ou vaccinales.

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