C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 41/00 (2006.01) A61K 31/07 (2006.01) A61K 31/19 (2006.01) A61K 31/20 (2006.01) A61K 31/203 (2006.01) A61K 31/23 (2006.01) A61K 31/232 (2006.01) C07C 57/26 (2006.01) C07C 59/46 (2006.01) C07C 59/80 (2006.01) C07K 14/705 (2006.01) C12P 7/04 (2006.01)
Patent
CA 2123223
In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid recep- tors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided ligands which are more selective for the retinoid X receptor than is retinoic acid (i.e., rexoids). In another aspect of the present invention, alternative ligands (other than retinoic acid) have been discovered which are capable of inducing retinoic acid receptor mediated processes. In yet another aspect, methods have been developed for the preparation of such retinoid receptor ligands from readily available compounds.
Boehm Marcus F.
Eichele Gregor
Evans Ronald M.
Heyman Richard A.
Mangelsdorf David J.
Baylor College Of Medicine
Gowling Lafleur Henderson Llp
Ligand Pharmaceuticals Inc.
The Salk Institute For Biological Studies
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