Measurement of glycated hemoglobin

Details Measurement of glycated hemoglobin Measurement of glycated hemoglobin

G - Physics

01

N

G01N 33/72 (2006.01) C07K 16/44 (2006.01)

Patent

CA 2306840

The invention features a novel method of assaying glycated hemoglobin (GHb) in a sample using a capture molecule e.g. haptoglobin that binds GHb and hemoglobin (Hb), and detecting bound GHb with a molecule that distinguishes GHb from non-glycated hemoglobin (Hb). The molecule used to distinguish GHb from Hb may be an antibody. The assay and antibodies of the invention are useful for the evaluation of GHb in disease states such as diabetes.

L'invention porte sur un nouveau procédé de titrage d'hémoglobine glycosylée (GHb) dans un échantillon au moyen d'une molécule de capture qui lie GHb et l'hémoglobine (Hb), et de détection de GHb liée avec une molécule qui distingue GHb de l'hémoglobine non glycosylée (Hb). La molécule utilisée pour distinguer GHb de Hb peut être un anticorps. Le titrage et les anticorps de cette invention sont utiles dans l'évaluation de GHb dans des états pathologiques tels que les diabètes.

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