Measuring degree of polymerisation for capsular saccharides...

Details Measuring degree of polymerisation for capsular saccharides... Measuring degree of polymerisation for capsular saccharides...

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 39/095 (2006.01)

Patent

CA 2567486

The degree of polymerisation (DP) is an important parameter for analysis of saccharide antigens, particularly in glycoconjugates. The invention provides methods that can be used to measure DP for capsular saccharides, particularly for meningococcal saccharides e.g. from serogroups W135 and Y. A preferred method is based on reduction of terminal sialic acid residues on saccharides, with DP then being calculated by comparing the molar ratio of total sialic acid to reduced sialic acid.

Le degré de polymérisation (DP) est un paramètre important pour l'analyse des antigènes saccharidiques, notamment dans des glycoconjugués. L'invention se rapporte à des procédés qui peuvent être mis en oeuvre pour mesurer le DP pour des saccharides capsulaires, notamment pour des saccharides méningococciques, par exemples des saccharides des sérogroupes W135 et Y. l'invention se rapporte à un procédé préféré fondé sur la réduction des résidus d'acide sialique terminal sur des saccharides, le DP étant calculé par comparaison du rapport molaire de l'acide sialique total à l'acide sialique réduit.

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