Mechanism mediating ruminal stasis in ruminal lactic acidosis

Details Mechanism mediating ruminal stasis in ruminal lactic acidosis Mechanism mediating ruminal stasis in ruminal lactic acidosis

A - Human Necessities

61

K

167/218, 167/227

A61K 31/505 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01)

Patent

CA 1321751

TITLE MECHANISM MEDIATING RUMINAL STASIS IN RUMINAL LACTIC ACIDOSIS INVENTOR Eugene C. Crichlow ABSTRACT OF THE DISCLOSURE Ruminal lactic acidosis develops in ruminant animals following the ingestion of large amounts of unac- customed feeds that are rich in readily fermentable carbo- hydrates. Characteristic symptoms of this disease include systemic acidosis, ruminal acidosis, forestomach stasis or forestomach hypomotility, inappetence, depression and hemoconcentration. Alpha-2 adrenoceptor antagonists have been found to be capable of re-establishing forestomach motility that has been lost or severely diminished in ruminants suffering from ruminal lactic acidosis. These antagonist compounds have also been found to be effective in the treatment of ruminants experiencing ruminal lactic acidosis.

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