C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2418386
Alterations to the transactivation (N-TAD) domain of HIF-1 alpha demonstrate this domain contains structures necessary for hypoxia-inducible transactivation, oxygen-dependent degradation, and VHL-HIF-1 alpha interaction. HIF-1 alpha sequences with alterations of the N-TAD domain, fragments and analogs thereof are useful in modifying or regulating the activity of bioentities. Agonists and antagonists of the N-TAD domain of HIF-1 alpha are also useful in modifying or regulating the activity of bioentities.
Des altérations du domaine de transactivation (N-TAD) de HIF-1 alpha démontrent que ce domaine contient des structures nécessaires à la transactivation inductible par l'hypoxie, à la dégradation dépendante de l'oxygène et à l'interaction entre VHL et HIF-1 alpha. Des séquences de HIF-1 alpha avec altérations du domaine N-TAD, des fragments et analogues, sont utiles dans la modification ou la régulation de l'activité de bioentités. Des agonistes et antagonistes du domaine N-TAD de HIF-1 alpha sont également utiles dans la modification ou la régulation de l'activité de bioentités.
Pereira Teresa
Poellinger Lorenz
Ruas Jorge
Angiogenetics Sweden Ab
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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