C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2421872
The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods fo inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.
L'invention concerne l'induction de la perméabilisation de la membrane mitochondriale via l'interaction physique et fonctionnelle de la protéine du HIV-1 Vpr avec l'ANT (translocateur nucléotidique d'adénine, également appelé adénine-nucléotide-translocase ou transporteur ADP/ATP) d'une protéine de la membrane interne mitochondriale. L'invention concerne également des réactifs et des méthodes permettant d'induire, et/ou inhiber la liaison de Vpr à ANT, la perméabilisation de la membrane mitochondriale, et l'apoptose.
Belzacq Anne-Sophie
Brenner-Jan Catherine
Edelmann Lena
Hoebeke Johan
Jacotot Etienne Daniel Francois
Centre National de La Recherche Scientifique
Institut National de La Sante Et de La Recherche Medicale-Inserm
Institut Pasteur
Robic
Universite de Technologie de Compiegne
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