A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61K 35/32 (2006.01) A61K 38/18 (2006.01) A61P 19/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2602479
The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP- 1, to overcome the dose-related translational barriers for BMP-2 therapeutics.
La présente invention concerne des méthodes et des compositions destinées au traitement de sujets présentant des conditions d'os fragilisés. Plus spécifiquement, l'invention concerne des stratégies thérapeutiques combinatoires faisant appel à des petites molécules et à des mimétiques peptidiques de protéines de minéralisation LIM, en particulier la LMP-1, afin de dépasser les barrières traductionnelles liées aux doses de thérapeutiques BMP-2.
Boden Scott D.
Marx Jeffrey C.
Mckay William F.
Boden Scott D.
Marx Jeffrey C.
Mckay William F.
Smart & Biggar
Warsaw Orthopedic Inc.
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