Meclofenamic acid topical pharmaceutical composition

A - Human Necessities – 61 – K

Patent

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A61K 31/195 (2006.01) A61K 47/00 (2006.01) A61K 47/02 (2006.01) A61K 47/06 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/44 (2006.01)

Patent

CA 1229554

ABSTRACT A clear gel and a cream pharmaceutical composition containing meclofenamic acid are disclosed. The clear gel composition is prepared by dissolving meclofenamic acid in polyethylene glycol monolaurate and polyekhylene glycol lanolin oil and adding isopropyl alcohol with mixing and finally adding colloidal silicon dioxide with mixing. The cream composition is prepared by adding meclofenamic acid or the sodium salt thereof to an emulsion prepared by mixing a warm aqueous solution of sorbic acid with a melt of poly- ethylene glycol monostearate, glyceryl monostearate, caprylic and capric triglyceride and mineral oil. The resulting compositions are indicated for the treatment of inflammation.

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