C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/056 (2006.01)
Patent
CA 2587489
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of- function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
La présente invention rend disponible des procédés et des réactifs pour empêcher des états de croissance aberrants résultant de gain de fonction hedgehog la mise en, de perte de fonction ptc ou de gain de fonction aplani comprenant contact de la cellule avec un hedgehog antagoniste de formule (I) en une quantité suffisante par rapport à l~état de croissance aberrant, par exemple, pour hésiter sur un chemin ptc normal ou contrarier une activité aplanie ou en hedgehog.
Boyd Edward Andrew
Brunton Shirley Ann
Guicherit Oivin M.
Mackinnon Colin H.
Price Stephen
Curis Inc.
Genentech Inc.
Parlee Mclaws Llp
LandOfFree
Mediators of hedgehog signaling pathways, compositions and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mediators of hedgehog signaling pathways, compositions and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mediators of hedgehog signaling pathways, compositions and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2001039