A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 9/08 (2006.01) A61K 31/4025 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2424785
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of function, ptc loss-of- function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
L'invention concerne des procédés et des réactifs destinés à inhiber des états de croissance aberrante résultant d'une augmentation de la fonction hedgehog, d'une perte de la fonction ptc ou d'une augmentation de la fonction smoothened. Les procédés comprennent une mise en contact de la cellule avec un antagoniste de hedgehog, p. ex. petite molécule, en quantité suffisante pour inhiber la croissance aberrante, p. ex. afin de produire un effet agoniste sur une voie de signalisation de ptc normale, ou un effet antagoniste sur l'activité de smoothened ou de hedgehog.
Baxter Anthony D.
Boyd Edward A.
Guicherit Oivin M.
Price Stephen
Rubin Lee L.
Borden Ladner Gervais Llp
Curis Inc.
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