A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2388468
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of- function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
La présente invention concerne des procédés et des réactifs permettant d'inhiber des états de croissance aberrants qui résultent de gain de fonction hedgehog, de perte de fonction ptc ou de gain de fonction smoothened. Selon cette invention, la cellule est mise en contact avec un antagoniste d'hedgehog, tel qu'une petite molécule, en quantité suffisante pour permettre un état de croissance aberrant, par exemple pour agoniser une voie ptc normale ou pour antagoniser l'activitésmoothened ou hedgehog.
Baxter Anthony David
Boyd Edward Andrew
Guicherit Oivin M.
Price Stephen
Rubin Lee
Borden Ladner Gervais Llp
Curis Inc.
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