Mediators to oxidoreductase enzymes

C - Chemistry – Metallurgy – 12 – M

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C12M 1/40 (2006.01) C12Q 1/00 (2006.01) C12Q 1/26 (2006.01) G01N 27/327 (2006.01) H05K 1/02 (2006.01)

Patent

CA 2115052

ABSTRACT OF THE DISCLOSURE Half-sandwich complexes of transition metals having a single .pi.-ligand with delocalised .pi. bonding are of use in mediating electron transfer between an electrode and a redox protein, for example an oxidoreductase enzyme such as in an amperometric enzyme sensor. Suitable compounds include complexes of the general formula :(.pi.-ligand)M(not-.pi.-ligand)n, wherein the complex is charges or neutral, .pi.-ligand) represents the single .pi.-bonded ligand, M represents the transition metal atom, n is the number of ligands which are not .pi.-ligands, and the n not-.pi.-ligands) are the same or different, are univalent or multivalent, and serve to satisfy the valency of the transition metal M.

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