C - Chemistry – Metallurgy – 09 – K
Patent
C - Chemistry, Metallurgy
09
K
167/158, 6/218
C09K 3/30 (2006.01) A61K 9/12 (2006.01)
Patent
CA 2280099
A pressure-liquefied propellant mixture for aerosols, comprising a fluorinated alkane, in particular 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, and carbon dioxide, makes possible an improvement of the wetting properties of pharmaceutically active compounds, with which the formulation problems existing with hydrofluoroalkanes in relation to suspension as we11 as solution aerosols can be overcome and thus improved medicinal aerosol formulations can be obtained. With the aid of carbon dioxide, it is also possible to specifically influence the pressure and thus the particle size distribution and also by displacement of oxygen from the hydrofluoroalkanes to improve the storage stability of oxidation-sensitive active compounds.
Mélange propulseur liquéfié par pression, pour aérosols, qui comporte un alcane fluoré, en particulier 1,1,1,2-tétrafluoroéthane et/ou 1,1,1,2,3,3,3-heptafluoropropane, et du dioxyde de carbone. Ledit mélange améliore les propriétés de mouillage de principes actifs pharmaceutiques, ce qui permet de surmonter les problèmes de formulation existants, liés aux hydrofluoroalcanes, concernant les aérosols en suspension et en solution et d'obtenir ainsi des formulations médicales améliorées pour aérosols. A l'aide de dioxyde de carbone, il est également possible d'influencer de manière ciblée la pression et, partant, la répartition des tailles de particules, et en éliminant l'oxygène des hydrofluoroalcanes, d'améliorer la stabilité de stockage de principes actifs sensibles à l'oxydation.
Herzog Kurt
Keller Manfred
Fetherstonhaugh & Co.
Jago Pharma Ag
Jagotec Ag
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