Medical compositions comprising 1,4-benzothiazepine...

A - Human Necessities – 61 – K

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Details

A61K 31/554 (2006.01) A61P 9/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2357038

The present invention relates to a medical composition for atrial fibrillation treatment, comprising a compound represented by the following formula [I]: Formula [I] (see formula I) [wherein R1 represents a hydrogen atom or lower alkoxy group; R2 represents a hydrogen atom, lower alkoxy group or phenyl group (wherein the phenyl group may be substituted with 1 to 3 substituents selected from a group consisting of a hydroxides group and a lower alkoxy group), (see formulas II or III) (wherein R3 represents an acyl group); X represents -CO- or -CH2-, and n represents an integer of 1 or 2.] The present invention also relates to a method of treating atrial fibrillation using said compound, and to the use of said compound for producing a medicine for atrial fibrillation treatment or salts thereof or prodrugs thereof.

La présente invention concerne des compositions médicamenteuses utilisées dans le traitement de la fibrillation auriculaire qui contiennent des composés représentés par la formule (I), ou bien des sels de ces composés ou des promédicaments contenant ces derniers. Dans la formule (I), R<1> représente hydrogène ou alcoxy inférieur; R<2> représente hydrogène, alcoxy inférieur, phényle (qui peut être substitué par un à trois substituants sélectionnés dans le groupe formé par les groupes hydroxyle et alcoxy inférieur); dans les formules (II) et (III) R<3> représente acyle; X représenteCO- ouH2-; et n a pour valeur 1 ou 2. On décrit des procédés de traitement de la fibrillation auriculaire à l'aide de ces composés et l'utilisation de ces derniers dans la préparation de médicaments destinés au traitement de la fibrillation auriculaire.

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