A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/404 (2006.01) A61K 31/396 (2006.01) A61K 47/10 (2006.01) A61K 47/40 (2006.01) A61P 13/10 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2466148
Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1- methyl-2-[1H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9 and a formulation vehicle. The formulation vehicle improves the solubility and stability of EO9. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
L'invention concerne des compositions de revêtement anti-cancéreuses renfermant 3-hydroxyméthyl-5-aziridinyl-1-1-méthyl-2-[1H-indole-4,7-dione]propénol (E09). Plus particulièrement, lesdites compositions de revêtement contiennent EO9 et un excipient de préparation. Cet excipient de préparation permet d'améliorer la solubilité et la stabilité de EO9. En outre, les compositions de revêtement peuvent renfermer des agents de revêtement qui engendrent une meilleure adhésion de la composition de revêtement sur la paroi de la vessie, lors d'une administration intravésicale de ladite composition.
Beijnen Jos H.
Nuijen Bastiaan
Pfadenhauer Ernie
Smart & Biggar
Spectrum Pharmaceuticals Inc.
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