Medical device

Details Medical device Medical device

A - Human Necessities

61

K

A61K 38/44 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2483096

The present invention relates to the use of a gene transfer product to reduce hyperplastic connective tissue growth after tissue trauma or implantation of a medical device. The present invention also relates to a medical device with improved biological properties for an at least partial contact with blood, bodily fluids and/or tissues when introduced in a mammalian body, which device comprises a core and a nucleic acid, encoding a product capable of leading to production of extracellular superoxide dismutase present in a biologically compatible medium. Said nucleic acid encodes a translation or transcription product, which is capable of inhibiting hyperplastic connective tissue growth and promoting endothelialisation in vivo at least partially on a synthetic surface of said core. The present invention also relates to a method of producing a medical device according to the invention.

La présente invention concerne l'utilisation d'un produit de transfert génique pour réduire la croissance hyperplasique de tissus conjonctifs après traumatisme ou implantation d'un dispositif médical. La présente invention concerne aussi un dispositif aux propriétés biologiques améliorées pour un contact au moins partiel avec le sang, les fluides anatomiques et/ou les tissus lorsqu'il est introduit dans le corps d'un mammifère. Ce dispositif comporte un noyau et un acide nucléique codant un produit capable de conduire à la production de superoxyde-dismutase extracellulaire présente dans un milieu biocompatible. Cet acide nucléique code un produit de traduction ou de transcription capable d'inhiber la croissance hyperplasique de tissus conjonctifs et de favoriser l'endothélialisation in vivo, au moins partiellement sur une surface synthétique de ce noyau. L'invention concerne également un procédé de production d'un dispositif médical selon l'invention.

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