Medical device for in vivo nitric oxide release

Details Medical device for in vivo nitric oxide release Medical device for in vivo nitric oxide release

A - Human Necessities

61

L

A61L 27/54 (2006.01) A61F 2/06 (2006.01) A61L 33/00 (2006.01) A61L 33/02 (2006.01)

Patent

CA 2294425

The preparation and use of medical devices are described. A thiol group agent is loaded onto a medical device such as a stent or a catheter. Preferably, the loading is accomplished onto a polymeric surface (22) that had been activated by water vapor RF plasma treatment. The thiol group agent is structured to exhibit sulfhydryl groups. These sulfhydryl groups are available for interaction with nitric oxide (NO) carriers such as nitrovasodilators. This interaction can take place in situ at an in vivo location within a vascular system, for example, in which the sulfhydryl groups would be delivered by the medical device while the NO carrier will be delivered by suitable pharmaceutical administration means. Alternatively, the NO carrier can be loaded onto the treated medical device surface at a suitable time prior to insertion of the medical device into the body, such as immediately before the initiation of a medical procedure such as stent delivery and implantation.

L'invention concerne la préparation et l'utilisation de dispositifs médicaux. Un agent du groupe thiol est placé sur un dispositif médical du type extenseur ou cathéter. De préférence, l'agent est placé sur une surface polymère activée par traitement plasma RF en vapeur d'eau. L'agent du groupe thiol est structuré pour présenter des groupes sulfhydryle, lesquels s'offrent à l'interaction avec des vecteurs de monoxyde d'azote (NO) comme les nitrovasodilatateurs. L'interaction peur intervenir in situ en un point in vivo du système vasculaire, par exemple, moyennant quoi les groupes sulfhydryle sont administrés par le dispositif médical alors que le vecteur de NO est administré par des moyens pharmaceutiques appropriés. Selon une variante, le vecteur de NO peut être placé sur la surface traitée du dispositif médical à un moment approprié avant l'insertion du dispositif médical dans le corps, par exemple immédiatement avant le lancement d'une procédure médicale comme l'introduction et l'implantation d'un extenseur.

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