Medical device having radio-opacification and barrier layers

Details Medical device having radio-opacification and barrier layers Medical device having radio-opacification and barrier layers

A - Human Necessities

61

L

A61L 31/18 (2006.01) A61L 31/12 (2006.01)

Patent

CA 2442057

A medical device such as a coronary stent is provided that can be visualized in vivo) while further aiding in the prevention of restenosis. The medical device comprises a core having a first layer disposed thereon. The first layer is made from a material that is radio-opaque so that the medical device may be visualized in-vivo. An outer layer is disposed onto and surrounds at least a portion of the first layer to provide a barrier layer between the radio-opaque inner layer and blood and/or tissue disposed within the patient's vessel. The outer surface of the outer layer may include a textured surface of micropores, grooves, cross-hatched lines to receive a therapeutic agent. Drugs and treatments which utilize anti-thombogenic agents and anti-proliferation agents may be readily deployed from the textured outer surface of the outer layer of the medical device.

L'invention concerne un appareil médical, tel qu'une prothèse endovasculaire coronaire, pouvant être visualisé <i>in vivo</i> et conçu pour prévenir la resténose. L'appareil médical comprend un noyau sur lequel est déposée une première couche. Cette première couche est fabriquée à partir d'un matériau opaque aux rayons, ce qui permet une visualisation <i>in vivo</i> de l'appareil médical. Une couche extérieure recouvre et entoure au moins une portion de la première couche, de manière à constituer une couche barrière entre la couche intérieure opaque aux rayons et le sang et/ou un tissu se trouvant dans un vaisseau du patient. La surface extérieure de la couche extérieure peut présenter une surface texturée pourvue de micro-pores, de rayures, de lignes quadrillées permettant de recevoir un agent thérapeutique. Des médicaments et des traitements utilisant des agents anti-thrombogéniques et des agents anti-prolifération, peuvent être rapidement diffusés depuis la surface extérieure texturée de la couche extérieure de l'appareil médical.

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