Medical device treated with a hydrophilic polymer composition

Details Medical device treated with a hydrophilic polymer composition Medical device treated with a hydrophilic polymer composition

A - Human Necessities

61

L

A61L 33/00 (2006.01) A61F 2/24 (2006.01) A61L 27/00 (2006.01) A61L 27/34 (2006.01) A61F 2/00 (2006.01) A61F 2/06 (2006.01)

Patent

CA 2216639

There is provided medical devices for use as cardiac, coronary or vascular prostheses, for example heart valves, coronary artery bypass grafts and arterial grafts. The devices described are at least partially coated or impregnated with a hydrophilic polymer composition which desirably contains of from 1 to 99 % by weight of water, preferably 50 to 95 % by weight of water. The hydrophilic polymer composition may be biodegradable and preferably contains a polyurethane. Optionally the hydrophilic polymer composition may contain a pharmaceutically active agent, for example an anti-coagulant, a thrombolytic agent or an antibiotic. The device may be treated with two or more hydrophilic polymer compositions in separate coatings; a triple-layered coating may be especially beneficial. The presence of the hydrophilic polymer coating is beneficial in reducing the thrombogenesis which may occur following implantation of the device

L'invention se rapporte à des dispositifs médicaux destinés à être utilisés comme prothèses cardiaques, coronaires ou vasculaires, telles que des valvules cardiaques, des pontages aortocoronariens par greffe et des greffes artérielles. Ces dispositifs sont au moins partiellement revêtus ou imprégnés d'une composition polymère hydrophile qui contient, de façon souhaitable, de 1 à 99 % en poids d'eau, de préférence de 50 à 95 % en poids d'eau. La composition polymère hydrophile peut être biodégradable et contient de préférence du polyuréthane. Elle peut éventuellement contenir un agent pharmaceutiquement actif tel qu'un anticoagulant, un agent thrombolytique ou un antibiotique. Le dispositif peut être traité avec au moins deux compositions polymères hydrophiles incluses dans des revêtements séparés; un revêtement triple couche peut être particulièrement efficace. Le revêtement polymère hydrophile agit favorablement dans la réduction des risques de thrombogenèse pouvant survenir après l'implantation du dispositif.

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