Medical device with coating that promotes endothelial cell...

Details Medical device with coating that promotes endothelial cell... Medical device with coating that promotes endothelial cell...

A - Human Necessities

61

L

A61L 31/16 (2006.01) A61F 2/82 (2006.01) A61K 9/00 (2006.01) A61L 27/14 (2006.01) A61L 27/28 (2006.01) A61L 27/54 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/02 (2006.01) A61L 31/04 (2006.01) A61M 1/14 (2006.01)

Patent

CA 2472031

Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting th progenitor endothelial cell to accelerate adhere nce, growth and differentiation of the bound cells into matureand functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vas cular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.

L'invention concerne des compositions et des procédés destinés à produire un dispositif médical, tel qu'un stent, une endoprothèse, une endoprothèse vasculaire synthétique, des valvules cardiaques, revêtu d'une matrice biocompatible qui contient des anticorps, des fragments d'anticorps, ou des petites molécules, qui reconnaissent, se lient et/ou interagissent avec un antigène de surface de cellule souche en vue d'immobiliser les cellules à la surface du dispositif. Le revêtement recouvrant le dispositif peut également contenir un composé ou un facteur de croissance en vue de promouvoir l'accélération de la fixation, de la croissance et de la différenciation des cellules endothéliales souches des cellules liées dans des cellules endothéliales fonctionnelles et matures sur la surface du dispositif afin de prévenir l'hyperplasie de l'intima. L'invention concerne également des procédés de préparation, notamment de dispositifs médicaux, de compositions, et des procédés destinés à traiter un mammifère atteint d'une maladie vasculaire telle que la resténose, l'athérosclérose ou d'autres types d'obstruction des vaisseaux.

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