Medical device with therapeutic agents

A - Human Necessities – 61 – M

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Details

A61M 25/00 (2006.01) A61L 27/54 (2006.01) A61L 29/16 (2006.01)

Patent

CA 2522408

A medical device is adapted for at least partial implantation into a body and includes first and second sections along the length of the device. A first therapeutic agent is associated with the first section and a second therapeutic agent is associated with the second section. The first therapeutic agent can be one or more antiproliferative, such as paclitaxel, a paclitaxel derivative, or a paclitaxel pro-drug, anti-coagulant, antithrombotic, thrombolytic, fibrinolytic, or combination thereof. The second therapeutic agent can be one or more antimicrobials, such as one or more antibiotics. Each of the first and second therapeutic agents can either be posited on one or more surfaces of the respective section, or impregnated within the section. The device can include a separator to space the first and second sections. A method of making a medical device and a method of establishing access to a vessel within a body are also provided.

L'invention porte sur un dispositif médical au moins partiellement implantable dans le corps et comprenant une première et une deuxième section se suivant dans le sens de la longueur. Un premier agent thérapeutique est associé à la première section et un deuxième agent thérapeutique est associé à la deuxième section. Le premier agent thérapeutique peut consister en un ou plusieurs antiproliférants tels que le paclitaxel, un de ses dérivés ou promédicament, un anticoagulant, un antithrombotique, un thrombolytique, un fibrinolytique, ou leur combinaison. Le deuxième agent thérapeutique peut consister en un ou plusieurs antibactériens tels qu'un ou plusieurs antibiotiques. On peut placer l'un ou l'autre des agent thérapeutiques sur une ou plusieurs surfaces de leur section respective, ou les y imprégner. Le dispositif peut de plus comporter une cloison séparant la première section de la deuxième. L'invention porte également sur un procédé de réalisation d'un dispositif médical et sur une méthode d'accès à un vaisseau corporel.

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