Medical devices and methods for delivery of nucleic acids

Details Medical devices and methods for delivery of nucleic acids Medical devices and methods for delivery of nucleic acids

A - Human Necessities

61

F

A61F 2/02 (2006.01) A61K 47/30 (2006.01) A61K 48/00 (2006.01) A61L 27/26 (2006.01) A61L 27/34 (2006.01) A61L 27/48 (2006.01) A61L 31/04 (2006.01) A61L 31/12 (2006.01)

Patent

CA 2730498

Embodiments of the invention include devices for the release of nucleic acids and related methods. In an embodi-ment, the invention includes an active agent eluting coating including a polymeric matrix, a cationic carrier agent disposed with the matrix, and an active agent disposed within the matrix, the active agent including nucleic acids substantially uncomplexed with the cationic carrier agent. In an embodiment, the invention includes a method of making an implantable medical device in-cluding selecting a concentration of a cationic carrier agent corresponding to a desired elution profile, combining a matrix forming polymer, an active agent, a solvent, and the cationic carrier agent to form a coating composition having the selected concentration of the cationic carrier agent, the active agent comprising nucleic acids, and depositing the coating composition onto the surface of a substrate. Other embodiments are included herein.

Des modes de réalisation de l'invention concernent des dispositifs pour libérer des acides nucléiques et des procédés associés. Dans un mode de réalisation, l'invention concerne un revêtement à élution d'agent actif comprenant une matrice polymère, un excipient cationique agencé avec la matrice, et un agent actif disposé à l'intérieur de la matrice, l'agent actif comprenant des acides nucléiques sensiblement non complexés avec l'excipient cationique. Dans un mode de réalisation, l'invention concerne un procédé de production d'un dispositif médical implantable consistant à sélectionner une concentration d'un excipient cationique correspondant à un profil d'élution voulu, à combiner un polymère formant matrice, un agent actif, un solvant et l'excipient cationique pour former une composition de revêtement présentant la concentration sélectionnée de l'excipient cationique, l'agent actif comprenant des acides nucléiques, et à déposer la composition de revêtement sur la surface d'un substrat. D'autres modes de réalisation sont décrits dans la description de l'invention.

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