A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 25/00 (2006.01) A61M 25/10 (2006.01) A61M 31/00 (2006.01)
Patent
CA 2524166
The present invention provides HDAC inhibitors for use in inhibiting proliferation and/or migration of smooth muscle cells. The present invention further provides medical devices coated with the HDAC inhibitors. The present invention also provides use of the medical devices in methods for inhibiting proliferation and/or migration of smooth muscle cells. Additionally, the present invention provides methods for inhibiting proliferation and/or migration of non-neoplastic smooth muscle cells. Finally, the present invention provides methods for preventing or treating restenosis after angioplasty or stent implantation in a subject.
L'invention concerne des inhibiteurs de HDAC servant à inhiber la prolifération et/ou la migration de cellules des muscles lisses. Elle concerne également des dispositifs médicaux revêtus par ces inhibiteurs de HDAC. Elle concerne également l'utilisation de ces dispositifs médicaux dans des procédés servant à inhiber la prolifération et/ou la migration de cellules des muscles lisses. Elle concerne, de plus, des procédés servant à inhiber la prolifération et/ou la migration de cellules des muscles lisses non néoplasiques. Elle concerne enfin des procédés servant à prévenir ou à traiter la resténose après l'angioplastie ou l'implantation d'un extenseur chez un patient.
Marks Andrew Robert
Marx Steven O.
Gowling Lafleur Henderson Llp
Marks Andrew Robert
Marx Steven O.
The Trustees Of Columbia University In The City Of New York
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