Medical devices and methods for regulating the tissue...

A - Human Necessities – 61 – L

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A61L 24/00 (2006.01) A61K 31/337 (2006.01) A61K 31/436 (2006.01) A61K 31/573 (2006.01) A61M 31/00 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2529754

Devices and methods for reducing, eliminating,preventing, suppressing, or treating tissue responses to hemostatic devices e.g., biological sealants or vascular procedures are disclosed. The invention employs a combination of resorbable, biocompatible matrix materials and a variety of therapeutic agents, such as antiproliferatives or antibiotics, applied to a vascular puncture or incision to achieve hemostasis following diagnostic or interventional vascular catheterizations and to treat neointimal hyperplasia and stenosis . A matrix of a material such as collagen provides a reservoir of a therapeutic agent such as rapamycin (sirolimus) and its derivatives and analogs for delivery at a tissue site at risk for vasculoproliferation, infection, inflammation, fibrosis or other tissue responses.

La présente invention concerne des dispositifs et des méthodes qui visent à réduire, éliminer, prévenir, supprimer ou traiter les réponses tissulaires à des dispositifs hémostatiques, tels que par exemple, des matières d'étanchéité biologique ou bien des procédures vasculaires. Cette invention comprend l'utilisation d'une combinaison de matières de matrices biocompatibles résorbables et une diversité d'agents thérapeutiques, tels que des antiprolifératifs ou des antibiotiques, qui sont appliqués sur une perforation ou une incision vasculaire afin d'effectuer l'hémostase suite au diagnostic ou à des cathétérisations vasculaires interventionnelles et de traiter l'hyperplasie de la néointima et la sténose. Une matrice formée d'une matière telle que le collagène constitue un réservoir d'un agent thérapeutique tel que la rapamycine (sirolimus) et ses dérivés et ses analogues pour l'apport au niveau d'un site tissulaire présentant un risque de prolifération vasculaire, d'infection, d'inflammation, de fibrose ou d'autres réponses tissulaires.

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