Medical devices comprising ionically and non-ionically...

Details Medical devices comprising ionically and non-ionically... Medical devices comprising ionically and non-ionically...

A - Human Necessities

61

L

A61L 29/00 (2006.01) A61F 2/02 (2006.01) A61F 2/04 (2006.01) A61L 29/14 (2006.01) A61L 31/00 (2006.01) A61L 31/14 (2006.01) C08B 37/00 (2006.01) A61F 2/06 (2006.01)

Patent

CA 2262523

Shaped medical devices, e.g. stents, having improved mechanical properties and structural integrity are disclosed. The devices commprise shaped polymeric hydrogels which are both ionically and non- ionically cross-linked and which exhibit improved structural integrity after selective removal of the cross-linking ions. Process for making such devices are also disclosed wherein an ionically cross- linkable polymer is both ionically and non-ionically crosslinked to form a shaped medical device. When implanted in the body, selective in-vivo stripping of the cross-linking ions produces a softer, more flexible implant having improved structural integrity.

Dispositifs médicaux façonnés tels que des extenseurs se caractérisant par de meilleures propriétés mécaniques et une intégrité structurale améliorée. Les dispositifs comprennent des hydrogels polymères façonnés qui sont réticulés à la fois ioniquement et non ioniquement et qui présentent une intégrité structurale améliorée après l'élimination sélective des ions de réticulation. Des procédés de fabrication de ces dispositifs sont égalment décrits dans lesquels un polymère réticulable ioniquement est à la fois réticulé ioniquement et non ioniquement pour former un dispositif médical façonné. Lorsqu'on implante un dispositif médical de ce type, l'élimination sélective in vivo des ions de réticulation produit un implant plus souple et flexible présentant une meilleure intégrité structurale.

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