A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/436 (2006.01) A61K 31/437 (2006.01) A61L 27/28 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)
Patent
CA 2460074
A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti- proliferative agents, anti-platelet agents, anti-inflammatory agents, anti- thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.
La présente invention concerne un dispositif médical comprenant une structure de support capable de contenir ou de supporter un porteur ou un excipient répondant aux normes pharmaceutiques, ce porteur ou cet excipient pouvant contenir un ou plusieurs agents ou substances thérapeutiques. La surface du porteur est de préférence recouverte d'un film et ce film contient les substances thérapeutiques, telles que des médicaments, par exemple. Les structures de support de ces dispositifs médicaux qui conviennent dans cette invention incluent, notamment, des stents coronariens, des stents périphériques, des cathéters, des greffons d'artère et de veine, des greffons de dérivation et des ballonnets d'apport de médicament utilisés dans le système vasculaire. Les médicaments qui conviennent pour cette invention incluent, notamment, les composés représentés par la formule (I). On peut utiliser ces médicaments en combinaison avec un autre médicament comprenant des agents antiprolifératifs, des agents anti-agrégant plaquettaire, des agents anti-inflammatoires, des agents antithrombotiques, des médicaments cytotoxiques, des agents inhibiteurs de liaison cytokine ou chimiokine, des inhibiteurs de la dédifférentiation cellulaire, des agents hypolipémiants, des inhibiteurs de métalloprotéinase matricielle, des médicaments cytostatiques ou des combinaisons de ces médicaments.
Burke Sandra E.
Chen Yen-Chih J.
Cromack Keith R.
Lecaptain Angela M.
Mollison Karl W.
Abbott Laboratories
Mbm Intellectual Property Law Llp
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