Medical devices incorporating deuterated rapamycin for...

Details Medical devices incorporating deuterated rapamycin for... Medical devices incorporating deuterated rapamycin for...

A - Human Necessities

61

L

A61L 29/16 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2505080

Deuterated rapaymcin can be controllably introduced target locations within the patient's body by using an implantable medical device having a structure incorporated with a therapeutic agent comprising a deuterated rapamycin. Representative deuterated rapamycins include epi-7-deuteromthyl rapamycin, 7,43-d6 rapamycin, 7-deuteromethyl rapamycin and 31,42-d2-rapamycin and isomers thereof, and mixtures thereof. The deuterated rapamycin can also be glycosylated.

On peut introduire de façon contrôlée de la rapamycine deutérée au niveau d'emplacements ciblés à l'intérieur du corps d'un patient par l'intermédiaire d'un dispositif médical implantable incorporant dans sa structure un agent thérapeutique contenant de la rapamycine deutérée. A titre d'exemple, des rapamycines deutérées consistent en épi-7-deutérométhyle rapamycine, 7,43-d¿6? rapamycine, 7-deutérométhyle rapamycine et 31,42-d¿2?-rapamycine, ainsi que leurs isomères et mélanges. Cette rapamycine deutérée peut également être glycosylée.

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