Medical devices visible under magnetic resonance imaging

Details Medical devices visible under magnetic resonance imaging Medical devices visible under magnetic resonance imaging

A - Human Necessities

61

L

A61L 29/18 (2006.01) A61K 49/18 (2006.01) A61L 29/14 (2006.01) A61L 31/14 (2006.01) A61L 31/18 (2006.01) G01R 33/28 (2006.01)

Patent

CA 2552888

A medical device comprising a substrate and a hydrogel coating disposed over at least a portion of the substrate surface. The hydrogel coating contains an MRI contrast agent and includes inner and outer regions. The inner region comprises a first hydrogel polymer, and the outer region comprises a second hydrogel polymer that can be the same as or different from the first hydrogel polymer. The inner region exhibits more absorption upon hydration than does the outer region. Examples of hydrogel polymers include polysaccharide and polypeptide hydrogel polymers such as alginic acid, hyaluronic acid, chitin, carboxymethyl cellulose, hydroxypropyl cellulose, collagen, and gelatin, as well as salts and copolymers thereof. Upon insertion or implantation of the medical device into a patient, the hydrogel coating is differentiable from the environment surrounding the hydrogel coating under magnetic resonance imaging.

L'invention concerne un dispositif médical, qui comprend un substrat et un revêtement d'hydrogel disposé sur au moins une partie de la surface du substrat. Le revêtement d'hydrogel contient un agent de contraste pour IRM et présente une zone intérieure et une zone extérieure. La zone intérieure comprend un premier polymère d'hydrogel, et la zone extérieure comprend un second polymère d'hydrogel pouvant être identique au ou différent du premier polymère d'hydrogel. La zone intérieure a un plus grand pouvoir d'absorption après hydratation que la zone extérieure. Des exemples de polymères d'hydrogel comprennent des polymères d'hydrogel à base de polypeptide, tels que l'acide alginique, l'acide hyaluronique, la chitine, la cellulose de carboxyméthyle, la cellulose d'hydroxypropyle, le collagène et la gélatine, ainsi que leurs sels et copolymères. Après insertion ou implantation du dispositif médical dans le patient, le revêtement d'hydrogel peut être différencié de l'environnement qui l'entoure par imagerie par résonance magnétique.

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