C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/56 (2006.01) A61K 38/46 (2006.01) C12N 9/24 (2006.01) C12N 9/40 (2006.01) C12N 15/54 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2365923
The invention provides highly purified .alpha.-Gal A, and various methods for purifying it; .alpha.-Gal A preparations with altered charge and methods for making those preparations; .alpha.-Gal A preparations that have an extended circulating half-life in a mammalian host, and methods for making same; and methods and dosages for administering an .alpha.-Gal A preparation to a subject.
La présente invention concerne une .alpha.-Gal A hautement purifiée, et divers procédés permettant de la purifier. L'invention concerne également des préparations à base de .alpha.-Gal A dont la charge est modifiée, ainsi que des procédés permettant de réaliser ces préparations. L'invention concerne en outre des préparations à base de .alpha.-Gal A présentant une demi-vie circulante étendue chez un mammifère hôte et les procédés d'élaboration correspondants. L'invention concerne enfin des procédés et des doses posologiques permettant d'administrer à un sujet une préparation à base de .alpha.-Gal A.
Borowski Marianne
Daniel Peter Francis
Kinoshita Carol M.
Schuetz Thomas J.
Selden Richard F.
Shire Human Genetic Therapies Inc.
Smart & Biggar
Transkaryotic Therapies Inc.
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