Medical products comprising a haemocompatible coating,...

A - Human Necessities – 61 – L

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A61L 31/16 (2006.01) A61K 31/727 (2006.01) A61L 33/08 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2484374

The invention relates to the use of polysaccharides containing the sugar structural element N-acylglucosamine for producing haemocompatible surfaces, in addition to methods for coating surfaces in a haemocompatible manner with said polysaccharides, the latter constituting the common biosynthetic precursor substances of heparin and heparan sulphates. The invention also relates to coated medical products, in particular stents, which contain paclitaxel as an antiproliferative active ingredient, in addition to the use of said stents for preventing restenosis.

L'invention concerne l'utilisation de polysaccharides, qui contiennent le groupe sucre N-acylglucosamine, pour la réalisation de surfaces hémocompatibles, ainsi que des procédés pour recouvrir de façon hémocompatible des surfaces à l'aide de ces polysaccharides, lesquels constituent les précurseurs biosynthétiques communs de l'héparine et des héparane sulfates. L'invention concerne également des produits médicaux recouverts selon l'invention, en particulier des stents, qui contiennent, comme principe actif, du paclitaxel, ainsi que l'utilisation de ces stents pour empêcher la resténose.

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