A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 29/14 (2006.01) A61L 29/04 (2006.01) A61L 33/00 (2006.01)
Patent
CA 2599609
To provide a medical treatment device wherein the antithrombotic property and lubricity of a coating formed on the surface can be maintained in a stable state for a long period and also to provide a method for manufacturing the same. A mixture solution for coating wherein a copolymer of methyl vinyl ether with maleic acid anhydride, a quaternary ammonium salt and a polyether block amide dissolved in an organic solvent are applied upon the surface of a substrate comprising synthetic resin to form a coating and then urokinase and heparin are impregnated in the coating of the medical treatment device. The synthetic resin comprising the substrate is polyurethane, polyvinyl chloride, nylon or nylon elastomer. The quaternary ammonium salt is tridodecylmethylammonium chloride. An alkaline treatment is applied to a predetermined part of a substrate upon which a coating has been formed by application of the mixture solution.
L'invention porte sur un dispositif médical de traitement à la surface duquel on forme un revêtement dont les propriétés antithrombotiques et lubrifiantes peuvent se maintenir à l'état stable pendant une longue période, et sur son procédé de fabrication. A cet effet on forme une solution de revêtement comportant un mélange d'un copolymère d'éther de méthyle/vinyle, d'anhydride d'acide maléïque, d'un sel d'ammonium quaternaire et d'un polyéther bloc amide, dissous dans un solvant organique, que l'on applique sur un substrat de résine synthétique pour former un revêtement que l'on imprègne ensuite d'urokinase et d'héparine. La résine synthétique peut être de polyuréthane, du chlorure de polyvinyle, du Nylon ou un élastomère de Nylon. Le sel d'ammonium quaternaire est du chlorure de tridodécylméthylammonium. On applique ensuite un traitement alcalin à la partie prédéterminée du substrat sur laquelle on a formé le revêtement par application de la solution de mélange.
Amano Kenichi
Nishitani Kyoko
Sano Tomokazu
Covidien Ag
Smart & Biggar
LandOfFree
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