Medical use for tachykinin antagonists

Details Medical use for tachykinin antagonists Medical use for tachykinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/08 (2006.01) A61K 31/44 (2006.01) A61K 31/57 (2006.01) A61K 38/08 (2006.01) A61K 45/06 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2078578

The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. (see formula I) wherein R represents the ring A (see formula II) or 2-pyridinyl or 2-pyridinyl-N-oxide; R1 is selected from halogen atoms and C1-alkyl, C1-4alkoxy, trifluoromethyl, and S(O)n C1-4alkyl groups; R2 and R3, which may be the same or different, each independently are selected from hydrogen and halogen atoms and C1-4alkyl, C1-4alkoxy, trifluoromethyl and cyano groups; n represents zero, 1 or 2; and pharmaceutically acceptable salts and solvates thereof.

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