Medical use of inhibitors of glutaminyl and glutamate cyclases

Details Medical use of inhibitors of glutaminyl and glutamate cyclases Medical use of inhibitors of glutaminyl and glutamate cyclases

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) A61K 31/395 (2006.01) A61K 31/4164 (2006.01) A61K 31/417 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/4745 (2006.01)

Patent

CA 2524009

The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screeing for such effectors, and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of conditions that can be treated by modulation of QC-~activity. Preferred compositions additionally comprise inhibitors of DP IV or DP IV-like enzymes for the treatment or alleviation of conditions that can be treated by modulation of QC- and DP IV-activity.

La présente invention concerne de nouveaux substrats physiologiques de glutaminyl-cyclases (QC, EC 2.3.2.5) de mammifères, de nouveaux effecteurs de QC, des méthodes de criblage desdits effecteurs, ainsi que l'utilisation desdits effecteurs et des compositions pharmaceutiques comprenant lesdits effecteurs pour le traitement d'états qui peuvent être traités par modulation de l'activité des QC. Des compositions préférées comprennent en outre des inhibiteurs de DP IV ou d'enzymes de type DP IV pour le traitement ou le soulagement d'états qui peuvent être traités par modulation de l'activité des QC et des DP IV.

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