Medicament capsules for rectal application

A - Human Necessities – 61 – K

Patent

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A61K 9/02 (2006.01) A61K 9/48 (2006.01)

Patent

CA 1163558

ABSTRACT OF THE DISCLOSURE The invention provides a novel means for the administration of a therapeutically effective ingredient in the form of a rectally applicable medicament capsule, in which the otherwise unavoidable extreme variation in the absorbability of the effective ingredient among the individuals rectally treated with the capsules is minimized. It has been unexpectedly found that, when the effective ingredient is contained in the capsule in the form of a liquid medicine, the osmotic pressure of the liquid content plays a very essential role in the absorption of the effective ingredient through the rectum and the variation in the absorbability of the effective ingredient among the individuals can be minimized when the osmotic pressure of the liquid content is substantially higher than the osmotic pressure of the rectal fluid with which the capsules are contacted and is in the range of from 350 to 2000m Osm/kg H2O.

383606

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