Medicament for inhibiting neutrophil elastase and cathepsin g

Details Medicament for inhibiting neutrophil elastase and cathepsin g Medicament for inhibiting neutrophil elastase and cathepsin g

A - Human Necessities

61

K

A61K 31/715 (2006.01) A61K 31/727 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2140890

A method and medicament for the inhibition of neutrophil elastase and cathepsin G in mammals comprising administer- ing a treatment effective amount of 2-O-desulfated heparin to a mammal in need thereof. The medicament preferably is adminis- tered by aerosolization or by intravenous (IV) injection. In specific embodiments of the invention, the ratio of 2-O-desulfated he- parin to elastase is greater than about 0.2 and less than about 2.0, or the ratio of 2-O-desulfated heparin to cathepsin G is greater than about 0.4 and less than about 2Ø Preferably, the 2-O-desulfated heparin medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, normal saline, and distilled water.

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