C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/20 (2006.01) A61K 31/4152 (2006.01) A61P 1/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2497955
The invention provides preventive and/or therapeutic drugs for inflammatory intestinal diseases which contain as the active ingredient pyrazolone derivatives represented by the general formula (I), physiologically acceptable salts thereof, or hydrates or solvates of both: (I) wherein R1 is hydrogen, aryl, alkyl, or alkoxycarbonylalkyl; R2 is hydrogen, aryloxy, arylmercapto, alkyl, or hydroxyalkyl; or R1 and R2 may be united to form alkylene; R3 is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, benzyl, naphthyl, phenyl, or phenyl mono- to tri-substituted with one or more members selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, alkoxycarbonyl, alkylmercapto, alkylamino, dialkylamino, halogeno, trifluoromethyl, carboxyl, cyano, hydroxyl, nitro, amino, and acetamido.
Cette invention se rapporte à des médicaments prophylactiques et/ou thérapeutiques contre les maladies intestinales inflammatoires, qui contiennent comme principe actif des dérivés de pyrazolone représentés par la formule générale (I), des sels physiologiquement acceptables de ces dérivés, ou des hydrates ou solvates de ces dérivés ou de ces sels. Dans cette formule, R?1¿ représente hydrogène, aryle, alkyle ou alcoxycarbonylalkyle; R?2¿ représente hydrogène, aryloxy, arylmercapto, alkyle ou hyroxyalkyle; ou R?1¿ et R?2¿ peuvent être unis pour former alkylène; R?3¿ représente hydrogène, alkyle, cycloalkyle, hydroxyalkyle, benzyle, naphtyle, phényle ou phényle mono à tri-substitué par un ou plusieurs des éléments choisis dans le groupe constitué par alkyle, alcoxy, hydroxyalkyle, alcoxycarbonyle, alkylmercapto, alkylamino, dialkylamino, halogéno, trifluorométhyle, carboxyle, cyano, hydroxyle, nitro, amino et acétamido.
Andoh Akira
Araki Yoshio
Fujiyama Yoshihide
Dennison Associates
Mitsubishi Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
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