Medicament for prevention and treatment of diabetes

Details Medicament for prevention and treatment of diabetes Medicament for prevention and treatment of diabetes

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61K 31/553 (2006.01) A61K 31/554 (2006.01) C07D 243/10 (2006.01) C07D 243/16 (2006.01) C07D 243/24 (2006.01) C07D 243/38 (2006.01)

Patent

CA 2312716

Drugs containing as the active ingredient compounds represented by general formula (I and II) and being useful in preventing and treating diabetes and complication thereof, wherein R1 represents hydrogen or C1-6 alkyl; R2 and R3 represent each hydrogen or C1-6 alkyl, or R2 and R3 may form together with the carbon atom on the phenyl ring to which they are bonded a 5- or 6-membered ring; R4 represents hydrogen, C1-6 alkyl, C1-6 alkoxy, etc.; R6 represents hydrogen or C1-6 alkyl; X represents -NR7-, -NO-, -O-, etc. (wherein R7 represents hydrogen, C1-6 alkyl, etc.); and Y represents phenylene or pyridinediyl.

L'invention concerne des médicaments contenant comme ingrédient actif des composés représentés par les formules générales I et II et s'utilisant dans la prévention et le traitement du diabète et de ses complications. Dans la formule selon l'invention, R?1¿ désigne un hydrogène ou un alkyle en C¿1-6?; R?2¿ et R?3¿ désignent chacun un hydrogène ou un alkyle en C¿1-6?, ou R?2¿ et R?3¿ peuvent former ensemble avec l'atome de carbone sur le noyau phényle auquel ils sont liés un noyau à 5 ou 6 éléments; R?4¿ désigne un hydrogène, un alkyle en C¿1-6?, un alcoxy en C¿1-6?, etc.; R?6¿ désigne un hydrogène ou un alkyle en C¿1-6?; X désigne -NR?7¿-, -NO-, -O-, etc. (R?7¿ désignant un hydrogène, un alkyle en C¿1-6?, etc.); et Y désigne un phénylène ou un pyridinediyle.

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