Medicament for prevention or treatment of fibrosis having...

Details Medicament for prevention or treatment of fibrosis having... Medicament for prevention or treatment of fibrosis having...

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 31/00 (2006.01) A61K 31/536 (2006.01) A61K 31/538 (2006.01) A61K 45/00 (2006.01) A61P 1/16 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 13/08 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 43/00 (2006.01) C07D 239/96 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2368366

Preventive or therapeutic drugs, which inhibit the progression of fibrogenesis in the skin or other various organs while preventing the progression of various complications, and are so safe by virtue of their being free from adverse effects as to bring about enhancement in the quality of daily life of a patient. Specifically, preventive or therapeutic drugs for fibrosis containing chymase inhibitors as the active ingredient, wherein the chymase inhibitors are quinazoline derivatives of the general formula (I) or pharmacologically acceptable salts thereof.

L'invention porte sur des médicaments préventifs ou thérapeutiques qui inhibent l'évolution de la fibrogenèse dans la peau ou autres organes et préviennent différentes complications. Ces médicament ne présentent pas de risque du fait qu'ils n'entraînent aucun effet secondaire et qu'ils contribuent à améliorer la qualité de vue du patient. De manière spécifique, ces médicaments préventifs ou thérapeutiques utilisés pour traiter la fibrose contiennent des inhibiteurs de chymase comme ingrédients actifs, ces inhibiteurs étant des dérivés de quinazoline de la formule générale (I) ou des sels de ceux-ci acceptables d'un point de vue pharmacologique.

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