Medicament for the treatment of viral skin and tumour diseases

Details Medicament for the treatment of viral skin and tumour diseases Medicament for the treatment of viral skin and tumour diseases

A - Human Necessities

61

K

A61K 31/23 (2006.01) A61K 31/12 (2006.01) A61K 31/20 (2006.01) A61K 31/25 (2006.01) A61K 31/353 (2006.01) A61K 45/06 (2006.01) A61K 47/06 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61P 17/00 (2006.01) A61P 31/20 (2006.01) A61P 31/22 (2006.01)

Patent

CA 2466720

The invention relates to a medicament containing a compound of general formula (I), where R1 = independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkinyl group, preferably a C11-C15 alkyl, alkylene or alkinyl group, particularly a C11-C13 alkyl, alkylene or alkinyl group, most preferably a C13 alkyl group, R2 = independently, a straight or branched C1-C8 alkyl, alkylene or alkinyl group, preferably a C1-C6 alkyl, alkylene or alkinyl group, in particular a C2-C4 alkyl, alkylene or alkinyl group, most preferably a C3 alkyl group, a -[CH2-(CH2)m-O]nH group with n = 1 to 10, preferably n = 1 to 5, m = 1 to 5, preferably m = 1 to 3, a -CH2-[CH-(OH)]p [CH2-(R3)]- group, where R3 = independently H or OH, p = 1 to 7, preferably p = 1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumour diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.

La présente invention concerne un médicament comprenant un composé de formule générale (I), dans laquelle R¿1? représente un radical alkyle C¿11?-C¿21?, alkylène ou alcinyle, ramifié ou non ramifié, saturé, mono-insaturé ou poly-insaturé, éventuellement substitué, de préférence un radical alkyle C¿11?-C¿15?, alkylène ou alcinyle, notamment un radical alkyle C¿11?-C¿13?, alkylène ou alcinyle, surtout un radical alkyle C¿13?, et R¿2? représente un radical alkyle C¿1?-C¿8?, alkylène ou alcinyle, ramifié ou non ramifié, de préférence un radical alkyle C¿1?-C¿6?, alkylène ou alcinyle, notamment un radical alkyle C¿2?-C¿4?, alkylène ou alcinyle, surtout un radical alkyle C¿3?, un radical -[CH¿2?-(CH¿2?)¿m?-O]¿n?-H avec n = 1 à 10, de préférence n = 1 à 5, m = 1 à 5, de préférence m = 1 à 3, un radical -CH¿2?-[CH-(OH)]¿p? [CH¿2?-(R¿3?)], R¿3? représente hydrogène ou un radical hydroxyle, p = 1 à 7, de préférence p = 1 à 4, un radical pentose ou un radical hexose. Ce médicament sert d'ingrédient actif thérapeutique, seul ou en combinaison avec un ou plusieurs autres ingrédients actifs pharmaceutiques sous forme de préparation combinée, pour traiter des maladies de peau virales et/ou des maladies tumorales, notamment induites par le virus du papillome humain (HPV) et/ou par le virus de l'herpès. La présente invention concerne également une préparation médicamenteuse à action topique et son utilisation.

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